Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-09-27
2005-09-27
Davis, Zinna Northington (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S333000, C514S345000, C514S352000, C546S256000, C546S257000, C546S290000
Reexamination Certificate
active
06949571
ABSTRACT:
The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof.In the formula, Q indicates NH, O or S; and R1, R2, R3, R4and R5are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6alkylene group etc.; and A indicates an optionally substituted C6-14aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
REFERENCES:
patent: 6133255 (2000-10-01), Harrison et al.
patent: 19643037 (1998-04-01), None
patent: 0802195 (1997-10-01), None
patent: 52083761 (1977-07-01), None
patent: 55031072 (1980-03-01), None
patent: WO94/25469 (1994-11-01), None
patent: WO95/01357 (1995-01-01), None
patent: WO96/10023 (1996-04-01), None
patent: WO 96/33974 (1996-10-01), None
patent: WO96/33974 (1996-10-01), None
patent: WO97/18163 (1997-05-01), None
patent: WO97/28135 (1997-08-01), None
patent: WO97/34878 (1997-09-01), None
patent: WO97/43276 (1997-11-01), None
patent: WO98/38173 (1998-09-01), None
patent: WO98/50384 (1998-11-01), None
patent: WO 98/50384 (1998-11-01), None
patent: WO98/55480 (1998-12-01), None
patent: WO 98/55480 (1998-12-01), None
patent: WO 99/31062 (1999-06-01), None
patent: WO99/31062 (1999-06-01), None
patent: WO00/01376 (2000-01-01), None
patent: WO00/07988 (2000-02-01), None
Earl et al, Journal of Organic Chemistry, vol. 49, pp. 4786-4800.
Adachi et al, Chemical Abstracts, vol. 131, Abstract No. 58848 , 1999 (abstract of WO 99/31062).
El-Kholy et al, Journal of the Chemical Society, pp. 4490-4498, 1961.
Castillo et al., The Lancet, vol. 349, pp. 79-83, (1997).
Nadin et al., Tetrahedron Letters, vol. 40, pp. 4073-4076, (1999).
Meldrum, B., Brain Research Reviews, vol. 18, pp. 293-314, (1993).
Arias et al., J. of Neuro Research, vol. 41, pp. 561-566, (1995).
Cha et al., Neuroscience Letters, vol. 132, pp. 55-58, (1991).
Nelson et al., Proc. Natl. Acad. Sci., vol. 87, pp. 269-273, (1990).
Rosenberg et al., Proc. Natl. Acad. Sci, vol. 88, pp. 4865-4869, (1991).
Smith et al., Neuroreport, vol. 5, pp. 1009-1011, (1994).
Dreyer et al., E. J. of Neuroscience, vol. 7, pp. 2502-2507, (1995).
Ushijima et al., E. J. of Neuroscience, vol. 7, pp. 1353-1359, (1995).
Sindou et al., J. of Neurological Sciences, vol. 126, pp. 133-137, (1994).
Muller et al., E. J. of Pharmacology, vol. 226, pp. 209-214, (1992).
Lipton, S., Neurology, vol. 42, pp. 1403-1405, (1992).
Hardin-Pouzet et al., GLIA, vol. 20, 79-85, (1997).
Gahring et al., Neurology, vol. 48, pp. 494-500, (1997).
Brusa et al., Science, vol. 270, pp. 1677-1680, (1995).
Shreadown et al., Science, vol. 247, pp. 571-574, (1990).
Turski et al., J. of Pharm. and Exp. Therapeutics, vol. 260, No. 2, pp. 742-747, (1992).
Kotlinska et al., Pharm. Bio. and Behavior, vol. 60, No. 1, pp. 119-124, (1998).
Yoshiyama et al., J. of Pharm. and Exp. Therapeutics, vol. 280, No. 2, pp. 894-904, (1997).
Gray et al., Neuroscience Letters, vol. 268, pp. 127-130, (1999).
Fujita et al., Yakugaku Zasshi, vol. 110, No. 6, pp. 449-452, (1990).
Nadin, A. et al., “Synthesis of tricycli cpyridones by radical cyclization”, Tetrahedron Letters, vol. 40, No. 21, pp. 4073-4076, (1999).
Fujita, R. et al., “Studies on 1-alkyl-2 (1H)-pyridone derivaties. XXXII. The Friedel-Crafts reaction of 1-alkyl-2 (1H)-pyridone derivatives with acid anhydride” Yakugaku Zasshi, vol. 110, No. 6, pp. 449-452, (1990).
Amino Hiroyuki
Groom Anthony John
Hanada Takahisa
Hatakeyama Shinji
Ito Koichi
Birch & Stewart Kolasch & Birch, LLP
Davis Zinna Northington
Eisai Co. Ltd.
LandOfFree
1,2-dihydropyridine compounds, process for preparation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,2-dihydropyridine compounds, process for preparation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,2-dihydropyridine compounds, process for preparation of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3392052