1,2-Dihydro-2-oxoquinol-4-ylacetic acid derivatives and pharmace

Details 1,2-Dihydro-2-oxoquinol-4-ylacetic acid derivatives and pharmace 1,2-Dihydro-2-oxoquinol-4-ylacetic acid derivatives and pharmace

1978-09-25

1980-02-05

Wheeler, David

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546154, 546157, A61K 31545, C07D21522

Patent

active

041873106

ABSTRACT:
Novel 1,2-dihydro-2-oxoquinol-4-ylalkanoic acid derivatives bearing a variety of substituents on the quinoline nucleus but including, at position 1, an aromatic radical linked directly or through a C.sub.1-4 -alkylene or a C.sub.2-4 -alkenylene radical. Representative compounds of the invention are 1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid and .alpha.-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid. The compounds possess anti-inflammatory or analgesic properties, or are inhibitors of the enzyme aldose reductase.

REFERENCES:
patent: 3772301 (1973-11-01), Strandtmann
Kegasawa et al., "Chemical Abstracts", 1968, vol. 69: 106,760(n).

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