Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-04-22
1994-07-26
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546276, A61K 3144, C07D40104
Patent
active
053327500
ABSTRACT:
New 1,2-dihydro-2-oxopyridines of formula I ##STR1## in which R is the radical ##STR2## and R.sup.1 to R.sup.6 and X are as defined herein,
and their salts, have antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
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*Zeffren, The Study of Enzyme Mechanism, p. 87, 1974.
*Wade, Jr., Organic Chemistry, p. 349, 1987.
Aumailley et al., FEBS Letters, vol. 291, No. 1, pp. 50-54 (Oct. 1991).
Smith et al., The Journal of Biological Chemistry, vol. 265, No. 21, pp. 12267-12271 (Jul. 25, 1990).
Beier Norbert
Lues Ingeborg
Mederski Werner
Minck Klaus-Otto
Schelling Pierre
Fan Jane T.
Merck Patent Gesellschaft mit beschrankter Haftung
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