1,2-dideoxy-2-fluoronojirimycin as glycosidase inhibitors

Details 1,2-dideoxy-2-fluoronojirimycin as glycosidase inhibitors 1,2-dideoxy-2-fluoronojirimycin as glycosidase inhibitors

1989-07-27

1991-06-18

Dentz, Bernard I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514315, 514328, 546116, 546219, 546220, 546242, A61K 31445, C07D21146, C07D491056

Patent

active

050250213

ABSTRACT:
Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.

REFERENCES:
patent: 4348402 (1982-09-01), Kinast et al.
Minavu et al, J. Org. Chem., 41 1831 (1976).
David et al, Tetrahedron, 41, (4), 643 (1985).
Tsuda et al, Chem. Pharm. Bull., 31(5), 1612 (1983).
Boshagan et al, Carbohydrate Research, 164, 141 (1987).

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