(1,2-dichloro-8-oxo-5a-substituted-5a,6,7,8 -tetrahydrodibenzofu

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...


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514320, 514402, 514422, 514468, 544333, 546196, 548348, 548525, 549460, A61K 3134, C07D30791




The invention relates to novel (1,2-dichloro-8-oxo-5a-substituted-5a,6,7,8-tetrahydrodibenzofuran-3-yl)al kanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections including that due to AIDS virus, various brain concussions and elevated intracranial pressure.

patent: 4316043 (1982-02-01), Cragoe et al.
patent: 4317922 (1982-03-01), Cragoe et al.
patent: 4337354 (1982-06-01), Cragoe et al.
patent: 4356313 (1982-10-01), Cragoe et al.
patent: 4356314 (1982-10-01), Cragoe et al.
patent: 4389417 (1983-06-01), Bourke et al.
patent: 4394385 (1983-07-01), Cragoe
patent: 4463208 (1984-07-01), Cragoe et al.
patent: 4465850 (1984-08-01), Cragoe et al.
patent: 4579869 (1986-04-01), Cragoe et al.
patent: 4604396 (1986-08-01), Cragoe et al.
J. Med. Chem. (1982) Cragoe, et al. 25 pp. 567-679.
J. Med. Chem. (1986) Cragoe, et al. 29 pp. 825-842.


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