Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-05-20
2009-06-23
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S358500
Reexamination Certificate
active
07550498
ABSTRACT:
The present invention relates to derivatives of 1,2-diaza-dibenzoazulene, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumor necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
REFERENCES:
patent: 3711489 (1973-01-01), Lombardino
patent: 3773940 (1973-11-01), Schindler et al.
patent: 3781294 (1973-12-01), Lombardino
patent: 3859439 (1975-01-01), Blattner and Schindler
patent: 4112110 (1978-09-01), Blattner
patent: 4198421 (1980-04-01), Cherkofsky et al.
patent: 4267184 (1981-05-01), Cherkofsky et al.
patent: 4267190 (1981-05-01), Cherkofsky et al.
patent: 4271179 (1981-06-01), van der Burg
patent: 7312203 (2007-12-01), Mercep et al.
patent: 7435834 (2008-10-01), Mercep et al.
patent: 2005/0148578 (2005-07-01), Mercep et al.
patent: 967573 (1975-05-01), None
patent: 0063525 (1982-10-01), None
patent: 0125484 (1984-11-01), None
patent: 0357126 (1990-03-01), None
patent: 0 372 445 (1990-06-01), None
patent: 20000310 (2002-02-01), None
patent: WO-91/18885 (1991-12-01), None
patent: WO 98/54186 (1998-12-01), None
patent: WO-01/87890 (2001-11-01), None
patent: WO 03/097648 (2003-11-01), None
Olivera et al., Dibenzoxepino ′4,5-d pyrazoles: a facile approach via the Ullman-ether reaction, Tetrahedron Letters, 2000, 41(22):4353-4360.
Kawashima and Kawano, Synthesis of Dibenzo-cycloprop-diazepine derivatives, J. Takeda Res. Lab, 1978, 37(1/2): 6-11.
Gansser et al., Determination de l'activite radioprotectrice d'analogues de l'imipramine, Ann. Pharmaceutique francaises, 1984, 41(5):465-471.
Fishou et al., Regioselective de la Cycloaddition Dipolaire-1,3, Tetrahedron, 1984, 40:5121-5133.
Elliott et al., Randomised double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis, The Lancet, 1994, 344:1105-1110.
Pfeffer et al., Mice Deficient for the 55kd Tumor Necrosis Factor Receptor Are Resistant to Endotixic Shock, yet Succumb to L. monocytogenes Infection, Cell, 1993, 73:457-467.
Keffer at al., Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis, EMBO J., 1991, 10:4025-4031.
Dinarello, Interleukin-1, Rev. Infect Disease, 1984, 6(1):51-95.
Bresnihan, Treatment with Recombinant Human Interleukin-1 Receptor Antagonist (rhIL-1ra) in Rheumatoid Arthritis (RA); Results of a Randomized Double-Blind, Placebo-Controlled Multicenter trial, Arthrit. Rheum., 1996, 39:73.
Menozzi, J. Heterocyclic Chem., 1997, 34:963-698.
Badger et al., Pharmacological Profile of SB 203580, a Selective Inhibitor of Cytokine Suppressive Binding Protein/p38 Kinase, in Animal Models of Arthritis, Bone Resorption, Endotoxin Shock and Immune Function, J. Pharmac. Env. Therap., 1996, 279(3):1453-1461.
Fukawa et al., A Method for Evaluating Analgesic Agents in Rats, J. Pharmacol. Meth., 1980, 4:251-259.
Schweizer et al., Combined automated writhing/motility test for testing analgesics, Agents and Actions, 1988, 23:29-31.
Collier et al., The Abdominal Constriction Response and Its Suppression By Analgesic Drugs in the Mouse, Br. J. Pharmac. Chemother., 1968, 32:295-310.
Dinarello, An Update on Human Interleukin-1: From Molecular Biology to Clinical Relevance, J. Clinical Immunology, 1985, 5:287.
Van Assche and Rutgeerts, Anti-TNF agents in Crohn's disease, Exp. Opin. Invest. Drugs, 2000, 9:103-111.
Georgopoulos et al., Transmembrane TNF Is Sufficient To Induce Localized Tissue Toxicity and Chronic Inflammatory Arthritis In Transgenic Mice, J. Inflamm., 1996, 46:86-97.
Mori et al., Attenuation of Collagen-Induced Arthritis in 55-kDa TNF Receptor Type 1 (TNFR1)-lgG1-Treated and TNFR1-Deficient Mice, J. Immunol., 1996, 157:3178-3182.
Carswell et al., An endotoxin-induced serum factor that causes necrosis of tumors, Proc. Natl. Acad. Sci. U.S.A., 1975, 72:3666-3670.
Bennett et al. “Reaction of 5-acetyl-10, didehydro-5H-dibenz[b,f] azepine with pyrrole, N-methylpyrrole, imada and n-methylimidazole: cycloaddition versus Michael addition.” J. Heterocycl. Chem., 1994, 31:293-296.
Bresnihan, “Treatment with recombinant human interleukin-1 receptor antagonist (rhIL-lra) in rheumatoid arthritis (RA); results of randomized double-blind, placebo-controlled multicenter trial,” Arthrit. Rheum., 1996, 39:73.
Funke et al. Physico-chemical properties and stability of trans-5-chloro-2methyl-2,3,3a,12b-tetrahydro-1-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine Maleate, Arzeim-Forsch., 1190, 40:536-539.
Mattioli and Ghia. “Omega-dialkylaminoalkyl ethers of phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with analgesic and anti-inflammatory activity.” J. Heterocyclic Chem., 1997, 34:963-968.
Novacek et al. “Reaction of 8-chloro-10-phenylhydrazono-10, 11-dihydro-dibenzo[b,f]thepine with aromatic aldehydes,” Collection Czechoslov. Chem. Commun., 1976, vol. 41, 785-787.
Schulz et al. “Synthese von 1,3a,3,12b-tetrahydro-dibenzo[b,f]-pyrazolo[3,4-d]azepin-Derivaten.” Z. Chem. 1988, 28:181-182.
Wermuth et al. “Molecular Variations Based on Isosteric Replacements,” Practice of Medicinal Chemistry, 1996, pp. 203-237.
Mercep Mladen
Mesic Milan
Pesic Dijana
GlaxoSmithKline Istrazivacki Centar Zagreb d.o.o.
Saeed Kamal A
Young J. Scott
LandOfFree
1,2-Diaza-dibenzoazulenes as inhibitors of tumour necrosis... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,2-Diaza-dibenzoazulenes as inhibitors of tumour necrosis..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,2-Diaza-dibenzoazulenes as inhibitors of tumour necrosis... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4128260