Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfur containing
Patent
1993-10-29
1994-09-06
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Sulfur containing
558413, 562429, 564 84, C07C31714, C07C31115, A61K 3110, A61K 3118
Patent
active
053449916
ABSTRACT:
A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein A is selected from ##STR2## each of R.sup.1 and R.sup.2 is independently selected from hydrido, methyl, ethyl, fluoro, hydroxymethyl, carbomethoxy, trifluoromethyl, carboxyl and fluoromethyl; wherein each of R.sup.3, R.sup.4, R.sup.6 through R.sup.9, R.sup.11 and R.sup.12 is independently selected from hydrido, methyl, fluoro and chloro; and wherein each of R.sup.5 and R.sup.10 is independently selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, methoxy, methylthio, cyano, trifluoromethyl, hydroxymethyl, methoxymethyl, methylsulfonyl and sulfamyl; provided that when A is ##STR3## R.sup.5 cannot be hydrido when R.sup.10 is selected from hydrido, cyano, halo, methyl, trifluoromethyl and methoxy; further provided that R.sup.10 cannot be hydrido when R.sup.5 is selected from cyano, halo, methyl, trifluoromethyl and methoxy; and further provided that R.sup.5 and R.sup.10 are not both methoxy; or a pharmaceutically suitable salt thereof.
REFERENCES:
patent: 3957795 (1976-05-01), Kubela et al.
patent: 4206220 (1980-06-01), Sloan
patent: 4229207 (1980-10-01), Laanio et al.
patent: 4393079 (1983-07-01), Cole et al.
patent: 4543207 (1985-09-01), Sato et al.
E. J. Corey et al., J. Amer. Chem. Soc., 85, 1788-1792, (1963).
D. Y. Curtin et al., J. Org. Chem., 36, 565-72, (1971).
O. P. Malik et al., Ind. J. Chem., 14B, 975-78, (1976).
Somers et al., J. Photochem. Photobio., 48A, 353-74, (1989).
W. H. Laarhoven, Pure & Appl. Chem., 56, 1225-40, (1984).
H. Ohashi et al., Phytochemistry, 31, 1371-1373, (1992).
Li Jinglin
Reitz David B.
Bulock Joseph W.
Dees Jos,e G.
Frazier Barbara S.
G.D. Searle & Co.
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