1,2 diarylcyclopentenyl compounds for the treatment of inflammat

Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfur containing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

558413, 562429, 564 84, C07C31714, C07C31115, A61K 3110, A61K 3118

Patent

active

053449916

ABSTRACT:
A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein A is selected from ##STR2## each of R.sup.1 and R.sup.2 is independently selected from hydrido, methyl, ethyl, fluoro, hydroxymethyl, carbomethoxy, trifluoromethyl, carboxyl and fluoromethyl; wherein each of R.sup.3, R.sup.4, R.sup.6 through R.sup.9, R.sup.11 and R.sup.12 is independently selected from hydrido, methyl, fluoro and chloro; and wherein each of R.sup.5 and R.sup.10 is independently selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, methoxy, methylthio, cyano, trifluoromethyl, hydroxymethyl, methoxymethyl, methylsulfonyl and sulfamyl; provided that when A is ##STR3## R.sup.5 cannot be hydrido when R.sup.10 is selected from hydrido, cyano, halo, methyl, trifluoromethyl and methoxy; further provided that R.sup.10 cannot be hydrido when R.sup.5 is selected from cyano, halo, methyl, trifluoromethyl and methoxy; and further provided that R.sup.5 and R.sup.10 are not both methoxy; or a pharmaceutically suitable salt thereof.

REFERENCES:
patent: 3957795 (1976-05-01), Kubela et al.
patent: 4206220 (1980-06-01), Sloan
patent: 4229207 (1980-10-01), Laanio et al.
patent: 4393079 (1983-07-01), Cole et al.
patent: 4543207 (1985-09-01), Sato et al.
E. J. Corey et al., J. Amer. Chem. Soc., 85, 1788-1792, (1963).
D. Y. Curtin et al., J. Org. Chem., 36, 565-72, (1971).
O. P. Malik et al., Ind. J. Chem., 14B, 975-78, (1976).
Somers et al., J. Photochem. Photobio., 48A, 353-74, (1989).
W. H. Laarhoven, Pure & Appl. Chem., 56, 1225-40, (1984).
H. Ohashi et al., Phytochemistry, 31, 1371-1373, (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

1,2 diarylcyclopentenyl compounds for the treatment of inflammat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,2 diarylcyclopentenyl compounds for the treatment of inflammat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,2 diarylcyclopentenyl compounds for the treatment of inflammat will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1330615

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.