1,2-Diaminocyclohexane platinum (II) complexes having antineopla

Details 1,2-Diaminocyclohexane platinum (II) complexes having antineopla 1,2-Diaminocyclohexane platinum (II) complexes having antineopla

1976-09-02

1978-09-19

Sneed, Helen M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424287, C07F 1500

Patent

active

041154185

ABSTRACT:
Organoplatinum complexes having antineoplastic activity against the L1210 mouse leukemia test system and having sufficient water-solubility for use in aqueous i.v. fluids. The organoplatinum complexes include malonato (1,2-diaminocyclohexane) platinum (II), hydroxymalonato (1,2-diaminocyclohexane) platinum (II), dinitrato (1,2-diaminocyclohexane) platinum (II), sulfato (1,2-diaminocyclohexane) platinum (II), and hydroxonitrato (1,2-diaminocyclohexane) platinum (II).

REFERENCES:
patent: 3892790 (1975-07-01), Tobe et al.
patent: 3904663 (1975-09-01), Tobe et al.
Ward et al., Cancer Treatment Reports, 60, No. 11, pp. 1675-1678 (1976).
Cleare et al., Bioinorganic Chemistry, vol. 2, pp. 187-210 (1973).
Connors et al., Chem. Biol. Interactions, vol. 5, pp. 415-424 (1972).
Gale et al, Research Communications in Chemical Pathology and Pharmocology, vol. 7, No. 3, pp. 529-538 (1974).
American Druggist, Pharmaceutical and Medical Science pp. 33 & 34, May 1969.

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