1,2-Diaminocyclohexane platinum (II) complexes having antineopla

Details 1,2-Diaminocyclohexane platinum (II) complexes having antineopla 1,2-Diaminocyclohexane platinum (II) complexes having antineopla

1977-11-29

1979-11-20

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

A61K 3128

Patent

active

041751337

ABSTRACT:
Organoplatinum complexes having antineoplastic activity against the L1210 mouse leukemia test system and having sufficient water-solubility for use in aqueous i.v. fluids. The organoplatinum complexes include malonato (1,2-diaminocyclohexane) platinum (II), hydroxymalonato (1,2-diaminocyclohexane) platinum (II), dinitrato (1,2-diaminocyclohexane) platinum (II), sulfato (1,2-diaminocyclohexane) platinum (II), and hydroxonitrato (1,2-diaminocyclohexane) platinum (II).

REFERENCES:
Cleave et al., Bioinorganic Chemistry, vol. 2, pp. 187-210, 1973.
Ward et al., Cancer Treatment Reports, vol. 60, No. 11, Nov. 1976, pp. 1675-1678.
Cleare et al., Plat. Metals Review, Jan. 1973, (7)(1), pp. 2-13.
Connors et al., Plat. Coordination Complexes in Cancer Chemotherapy, 1974, p. 117.

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