1,2-diaminocyclohexane-platinum complexes with antitumor activit

Details 1,2-diaminocyclohexane-platinum complexes with antitumor activit 1,2-diaminocyclohexane-platinum complexes with antitumor activit

1990-12-20

1992-07-21

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

514 23, 514184, A61K 3128, A61K 3170, A61K 31555

Patent

active

051323230

ABSTRACT:
The invention relates to a process for the treatment of tumors in animals with water soluble square-planar cis platinum(II) four-coordinate complexes comprising different nonovalent and divalent organic cations. Monovalent cations include galacturonato and N,N-dimethylglycinato and divalent cations include citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, isopropyl, n-butyl, secbutyl, ter-butyl, n-amyl, isoamyl or --OH. The treatment of animals comprises administering to the animals a pharmaceutical composition comprising a platinum complex of the composition described.

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