1,2-diamino compounds, process for their preparation and pharmac

Details 1,2-diamino compounds, process for their preparation and pharmac 1,2-diamino compounds, process for their preparation and pharmac

1988-08-11

1990-05-08

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514428, 544238, 544335, 544372, 546281, 548134, 548127, 548143, 548186, 548247, 548255, 5482672, 548374, 548517, 548526, 548527, 548569, 549495, A61K 3140, C07D29508

Patent

active

049238892

ABSTRACT:
Compounds are disclosed, including 2-diethylamino-3-isobutoxy-N-phenyl-N-2-furanyl-methyl-propylamine and compounds of the formula: ##STR1## wherein R.sub.1 is an iso-C.sub.4 -C.sub.6 -alkyl radical; A is a valency bond or a straight-chained or branched alkyl radical containing up to 6 carbon atoms; R.sub.4 is a phenyl radical which is unsubstituted or substituted one or more times by C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.1 -C.sub.3 -alkoxy, C.sub.2 -C.sub.6 -alkenyloxy, hydroxy-C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkylenedioxy, hydroxy-C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.3 -alkoxy-C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.6 -alkylamino, di(C.sub.1 -C.sub.6 -alkyl)amino, C.sub.1 -C.sub.3 -alkoxycarbonyl-C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulphinyl, C.sub.1 -C.sub.6 -alkylsulphonyl, C.sub.1 -C.sub.6 -alkylsulphonyloxy, carboxyl, C.sub.1 -C.sub.3 -alkoxycarbonyl, aminocarbonyl, mono- or di(C.sub.1 -C.sub.6 -alkyl)aminocarbonyl, halo-C.sub.1 -C.sub.6 -alkyl, cyano, or halogen; and R.sub.5 is a benzyl radical substituted at least once by C.sub.1 -C.sub.3 -alkoxy. The compounds are useful for the treatment of heart circulatory diseases.

REFERENCES:
patent: 3962238 (1976-06-01), Mauvernay et al.
patent: 4620015 (1986-10-01), Stiefel
patent: 4645778 (1987-02-01), Monteil et al.
patent: 4727072 (1988-02-01), Grous et al.
patent: 4758563 (1988-07-01), Grous et al.

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