1, 2-dialkoxyethanes as 5-lipoxygenase inhibitors

Details 1, 2-dialkoxyethanes as 5-lipoxygenase inhibitors 1, 2-dialkoxyethanes as 5-lipoxygenase inhibitors

1994-09-12

1995-12-12

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546157, A61K 3147, C07D21514

Patent

active

054750091

ABSTRACT:
Compounds of the structure ##STR1## where Ar.sup.1 is selected from optionally substituted carbocyclic aryl; optionally substituted 5- or 6-membered heterocyclic aryl; optionally substituted 10-membered bicyclic heterocyclic aryl containing one or two nitrogen atoms; optionally substituted benzo[b]furyl; optionally substituted benzo[b]thienyl; ##STR2## L.sup.1 is a valence bond, alkylene, propenylene, or propynylene; Y is oxygen, >NR.sup.5, or >S(O)n; Ar.sup.2 is optionally substituted phenyl; L.sup.2 is ##STR3## and R.sup.1 and R.sup.2 are alkyl, or taken together define a group of formula ##STR4## are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

REFERENCES:
patent: 5217977 (1993-06-01), Crawley et al.
patent: 5350754 (1994-09-01), Crawley et al.
patent: 5407945 (1995-04-01), Bruneau et al.

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