1,2 chemiluminescent dioxetanes of improved performance

Details 1,2 chemiluminescent dioxetanes of improved performance 1,2 chemiluminescent dioxetanes of improved performance

1995-10-25

1997-10-21

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549214, 549332, 536 41, C07F 906, C07F 702

Patent

active

056798032

ABSTRACT:
A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or chemical trigger admixed with the dioxetane. The polycyclic stabilizing group is preferably spiroadamantane. The group further bears an alkoxy, aryloxy, aralkyloxy or cycloalkyloxymoiety which is partially or completely substituted with halogens, particularly fluorine and chlorine. Proper selection of electron active groups on the stabilizing moiety, the aryl group and the OR group yields enhanced enzyme kinetics, superior light intensity and excellent detection sensitivity in various assays.

REFERENCES:
patent: 4931223 (1990-06-01), Bronstein et al.
patent: 4931569 (1990-06-01), Edwards et al.
patent: 4952707 (1990-08-01), Edwards et al.
patent: 4956477 (1990-09-01), Bronstein et al.
patent: 4962192 (1990-10-01), Schaap
patent: 4978614 (1990-12-01), Bronstein
patent: 5089630 (1992-02-01), Bronstein et al.
patent: 5112960 (1992-05-01), Bronstein et al.
patent: 5145772 (1992-09-01), Voyta et al.
patent: 5220005 (1993-06-01), Bronstein
patent: 5326882 (1994-07-01), Bronstein et al.
patent: 5330900 (1994-07-01), Bronstein et al.
patent: 5336596 (1994-08-01), Bronstein et al.
patent: 5438146 (1995-08-01), Schaap et al.
Communication received by Irena Bronstein at Tropix, Inc., 2 pgs. from A. Paul Schaap, Ph.D.

Affiliated with

Also associated with

Rating

1,2 chemiluminescent dioxetanes of improved performance does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,2 chemiluminescent dioxetanes of improved performance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,2 chemiluminescent dioxetanes of improved performance will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1007798