1,2-Biguanides

Details 1,2-Biguanides 1,2-Biguanides

1974-07-09

1976-06-01

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239AA, 2602475R, 260268R, 26029387, 260307R, 260307F, 26032686, C07C12916

Patent

active

039609499

ABSTRACT:
1,2-Substituted biguanides of the formula ##EQU1## wherein R.sub.1 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; a cycloalkyl group of 3-6 carbon atoms; or an aryl or aralkyl group of the formula ##SPC1##
With n being the integer 0, 1 or 2 and X being hydrogen or halogen; and R'.sub.1 is a hydrogen atom or a saturated or unsaturated, straight-chain or branched hydrocarbon group of 1-12 carbon atoms; or R.sub.1 and R'.sub.1 collectively with the nitrogen atom to which they are attached are a heterocyclic ring containing one or more hetero atoms; and R.sub.2 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; or cycloalkyl of 3-6 carbon atoms, alkoxyalkyl containing a total of 2-12 carbon atoms, or alkoxy of 1-6 atoms; mixtures thereof, and pharmaceutically acceptable acid addition salts thereof, are useful in the treatment of diabetes mellitus.

REFERENCES:
patent: 3170925 (1965-02-01), Doub
Chem. Abstr., vol. 49, col. 14,186(d) (1955).
Chem. Abstr., vol. 43, col. 3793(b) (1949).
Chem. Abstr., vol. 43, col. 9039(i) (1949).
Chem. Abstr., vol. 57, col. 16,618(a) (1962).

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