1,2-beta-methylene-4-substituted androstene-3,17-dione derivativ

Details 1,2-beta-methylene-4-substituted androstene-3,17-dione derivativ 1,2-beta-methylene-4-substituted androstene-3,17-dione derivativ

1987-08-18

1989-03-07

Sneed, H. M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260349, 514178, C07J 1100, A61K 3156, C07C11700

Patent

active

048104230

ABSTRACT:
The invention relates to new aromatase inhibitor agents having the general formula (I) ##STR1## wherein R.sub.1 is hydrogen or a group=CHR.sub.3 wherein R.sub.3 is hydrogen or C.sub.1 -C.sub.6 alkyl; the symbol indicates the presence of a single or double bond in such a way that, when R.sub.1 is hydrogen, (a) is single bond and (b) is either single or double bond, while, when R.sub.1 is a group.dbd.CHR.sub.3 as defined above, (a) is double bond and (b) is single bond; R.sub.2 is hydrogen or fluorine; and R is
(1) a group --OR.sub.4 wherein R.sub.4 is

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