1-[[2-amino-3-(substituted...

Details 1-[[2-amino-3-(substituted... 1-[[2-amino-3-(substituted...

2006-06-20

2011-10-11

Seaman, D M (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S305400

Reexamination Certificate

active

08034835

ABSTRACT:
Inhibitors of RSV replication of formula (I) which can be represented by formula (I)the salts and stereochemically isomeric forms thereof, whereinR is a radical of formulaQ is hydrogen or C1-6alkyl optionally substituted with a heterocycle or Q is C1-6alkyl substituted with both a radical —OR4and a heterocycle; Alk is C1-6alkanediyl;X is O or S; -a1=a2-a3=a4- is —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH— or —CH═CH—CH═N—; R1is Ar or a heterocycle;R2is hydrogen, C1-6alkyl, substituted C1-6alkyl, C3-7cycloalkyl; R3is hydrogen, C1-6alkyl, cyano, aminocarbonyl, polyhaloC1-6alkyl, C2-6alkenyl or C2-6alkynyl;R4is hydrogen or C1-6alkyl; Ar is phenyl or substituted phenyl; Het is a heterocycle; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).

REFERENCES:
patent: WO 01/00611 (2001-01-01), None
patent: WO 01/00612 (2001-01-01), None
patent: WO 01/00615 (2001-01-01), None
patent: WO 01/95910 (2001-12-01), None
patent: WO 2005/058869 (2005-06-01), None
Patani et al. Chem. Rev. (1996), vol. 96, pp. 3147-3176.

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