1,2,5,6-Tetrahydro-4H-pyrrolo(3,2,1-j)quinolin-2-ones

Details 1,2,5,6-Tetrahydro-4H-pyrrolo(3,2,1-j)quinolin-2-ones 1,2,5,6-Tetrahydro-4H-pyrrolo(3,2,1-j)quinolin-2-ones

1975-06-23

1977-03-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260283R, 260289R, 260289C, C07D47106

Patent

active

040150054

ABSTRACT:
The invention discloses 1,2,5,6-tetrahydro-4H-pyrrolo-(3,2,1-ij)quinolin-2-ones having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by treating a haloacetyl derivative of 1,2,3,4-tetrahydroquinoline with a Friedel-Crafts catalyst. The haloacetyl derivative of 1,2,3,4-tetrahydroquinoline may be prepared by reacting 1,2,3,4-tetrahydroquinoline with a haloacetyl halide at a mole ratio of 2:1 in the presence of an inert, organic solvent.

REFERENCES:
patent: 3917838 (1975-11-01), Bass et al.
Nagarajan et al.; Tetrahedron, vol. 23, (1967) pp. 1683-1690.
Rapaport; Chem. Abst. vol. 53 (1958) 8139g.
Kato et al.; Chem. Pharm. Bull., vol. 19, pp. 832-836 (1971).

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