(1,2,4)triazolo(4,3-a)quinoxaline-4-amines

Details (1,2,4)triazolo(4,3-a)quinoxaline-4-amines (1,2,4)triazolo(4,3-a)quinoxaline-4-amines

1986-12-08

1988-10-25

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544346, C07D48704, C07D24144, A61K 31495, C07B 3900

Patent

active

047804645

ABSTRACT:
A unique series of [1,2,4]triazolo[4,3-a] quinoxaline-4-amine derivatives which show excellent binding affinity at both the A.sub.1 and A.sub.2 adenosine receptor sites. The compounds are useful in treating depression, fatigue, and heart failure. Also disclosed are methods for preparing the compounds, compositions containing the compounds and methods for using them.

REFERENCES:
patent: 4242344 (1980-12-01), Lumma
patent: 4495187 (1985-01-01), Sarges
patent: 4623725 (1986-11-01), Kadin
Snyder et al., Proc. Natl. Acad. Sci 78, 3260 (1981).
Ukena, Fed. Europ. Bio. Chem. Soc 209, 122 (1986).

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