Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
The invention relates to the use of compounds having pharmacological activity towards the sigma receptor, and more particularly to 1,2,4-triazole derivatives of formula (I) to processes of preparation of such compounds and to pharmaceutical compositions comprising them.
patent: 3632345 (1972-01-01), Marx et al.
patent: 6638954 (2003-10-01), Kadaba
patent: 9109594 (1991-07-01), None
patent: 0236119 (2002-05-01), None
patent: 03092681 (2003-11-01), None
patent: 2004096781 (2004-11-01), None
patent: 2005039550 (2005-05-01), None
patent: 2005039569 (2005-05-01), None
patent: 2006092731 (2006-09-01), None
CAS Registry compounds #511306-31-3 and 522306-23-3, copyright date 2006.
Walker, J.M. et al., “Sigma Receptors: Biology and Function”, Pharmacological Reviews, 1990, 42, 355.
Snyder, S.H., et al., “Receptor Mechanisms in Antipsychotic Drug Action: Focus on Sigma Receptors”, Journal of Neuropsychiatry, 1989, 1, 7.
Quirion, R. et al. “A proposal for the classification of sigma binding sites”, Trends Pharmacol. Sci, 1992, 13:85-86.
Hanner, M. et al., “Purification, molecular cloning, and expression of the mammalian sigma1-bindng site”, Proc. Natl. Acad. Sci., 1996, 93:8072-8077.
Czollner, L. et al., “A Facile Synthesis of 1,5-Diphenyl-3-(substituted oxy)-1H-1,2,4-triazoles”, Arch. Pharm. 1990, 323 (4), 221-223.
DeHaven-Hudkins, D.L. et al., “Characterization of the binding of [3H](+)-pentazocine to σ recognition sites in guinea pig brain”, Eur. J. Pharmacol.; 1992, 227, 371-378.
Lowry, O.H., et al., Protein Measurement With the Folin Phenol Reagent, J. Biol. Chem, 1951, 193, 265.
Maliszewska-Guz, A. et al., “Derivatives of hydroxy-1,2,4,-triazole. Part III. Reaction of hydroxy-1,2,4-triazoles with ethylene chlorohydrin”, Annales Universitatis Mariae Curie-Sklodowska, Sectio AA: Chemia 1995, Volume Date 1991-1992, 46-47, 35-40 (abstract in English).
SciFinder search results, Copyright © 2006, American Chemical Society.
International Search Report for PCT/EP2007/062006, dated Mar. 17, 2008.
Cuberes-Altisent Maria Rosa
Cumella-Montanchez Jose Maria
Dordal Zueras Alberto
Goya-Laza Maria Pilar
Hoffmann & Baron , LLP
Laboratorios Del Dr. Esteve, S.A.
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