1 2 4-triazole compound

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S262200

Reexamination Certificate

active

07074816

ABSTRACT:
A novel 1,2,4-triazole compound which is useful as a therapeutic agent for hyperuricemia and gout due to hyperuricemia is provided. A compound is represented by the following general formula (1):wherein R2represents an unsubstituted or substituted pyridyl group, R1represents a similar pyridyl group, a pyridine-N-oxide group corresponding to these pyridyl groups, or a phenyl group, and R3represents hydrogen or a lower alkyl group substituted with pivaloyloxy group and R3bonds to a nitrogen atom in the ring. A process for production of a compound by reacting a nitrile and a hydrazide, and a therapeutic agent, particularly a xanthine oxidase inhibitor are also provided.

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Geldard, J.F. et al., J. Org. Chem.; 1965; 30(1); 318-319, especially p. 319, starting line 33.
Lever, A.B.P., Inorg. Chem; 1990; 29; 1271-1285, especially p. 1275, line 18 and 19.
Baldwin, J.J., J. Med. Chem.; 1975; 18(9); 895-900, especially p. 898, lines 3-5.

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