[1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists

Details [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists

2005-04-05

2005-04-05

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S263000, C544S295000, C544S324000, C546S117000

Reexamination Certificate

active

06875772

ABSTRACT:
Compounds having the structural formula Iwherein:n is 0, 1, 2 or 3;A is C(R1) or N;R1and R1aare H, (C1-C6)-alkyl, halo, CN or —CF3;X is —C(O)—, —O—, —SO0-2—, or optionally substituted methylene, imino, arylene or heteroaryldiyl;Y is —O—, —SO0-2—, or optionally substituted arylene, heteroaryldiyl, or nitrogen-containing heterocycloalkyl, or with certain provisos, a bond;R is optionally substituted-aryl or heteroaryl; andR2is optionally substituted aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R2—Y is a fused piperidinyl, substituted piperazinyl or substituted piperidinyl;their use in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, pharmaceutical compositions comprising them and kits comprising the components of the combinations.

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