1,2,4-triazinone derivatives, their preparation and use

Details 1,2,4-triazinone derivatives, their preparation and use 1,2,4-triazinone derivatives, their preparation and use

1987-03-16

1990-02-06

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544242, 5442318, 5442322, 5442278, 544182, 544 60, 544112, 544 83, 544 586, 540598, 540575, 514218, 514212, C07D25306, C07D40112, C07D40312, A61K 3153

Patent

active

048988626

ABSTRACT:
Compounds of formula (I): ##STR1## (in which: R.sup.1 is hydrogen or alkl; R.sup.2 is a variety of groups or atoms; R.sup.3 is optionally substituted hydroxy or --(NH).sub.n --NR.sup.5 R.sup.6, wherein R.sup.5 and R.sup.6 are a variety of groups or atoms, preferably alkyl substituted by heterocyclic, and n is 0 or 1; Q is oxygen or sulfur; and A is a C.sub.1 -C.sub.6 alkylene group) have valuable cardiotionic activity and may be used for the treatment of cardiac disorders. They may be prepared from corresponding compounds containing a benzene ring with a group --QH at the 1-position and a group --CO--CHR.sup.1 --NH--COOR.sup.7 at the 4-position by ring closure and introduction of the group of formula --A--CO--R.sup.3 in any order.

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