1,2,4-triazines

Details 1,2,4-triazines 1,2,4-triazines

1984-10-22

1987-03-10

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544182, C07D25306, A61K 3153

Patent

active

046491392

ABSTRACT:
Compounds of Formula I are novel and useful as cardiovascular agents, particularly anti-arrhythmic agents: ##STR1## or the 5-imino-tautomer thereof or a salt of either, wherein R.sup.1 is C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl or C.sub.3-10 cycloalkyl, any of which is optionally substituted, and R.sup.2 to R.sup.6 are independently selected from hydrogen, halogen atom, C.sub.1-6 alkyl, alkenyl or alkynyl (all optionally substituted by one or more of halogen, hydroxy and aryl, amino, mono- or di-substituted amino, alkoxy (optionally substituted by one or more of halogen, hydroxy and aryl), alkenyloxy, aryl, acyloxy, cyano, nitro, aryl and alkylthio groups or any adjacent two of R.sup.2 to R.sup.6 are linked to form a (--CH.dbd.CH--CH.dbd.CH--) group.

REFERENCES:
patent: 3637688 (1972-01-01), Rees et al.
patent: 3752808 (1973-08-01), Jautelat et al.

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