Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-08-29
1999-11-16
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544182, A61K 3153, C07D253075
Patent
active
059858753
ABSTRACT:
The present invention relates to compounds represented by the formula: ##STR1## wherein R.sup.1 is (1) an optionally substituted alkyl group which may be bonded through a hetero atom, (2) an optionally substituted acyl group, (3) an alkylsulfonyl group, (4) an alkylsulfinyl group, or (5) an optionally substituted sulfamoyl group; A is --N.dbd. or -CH.dbd.; R.sup.2 is a hydrogen atom or an alkyl group which may optionally be substituted with halogen and which may be bonded through a hetero atom;
REFERENCES:
patent: 3883527 (1975-05-01), Brennan
patent: 3883528 (1975-05-01), Mylari
patent: 3896124 (1975-07-01), Mylari
patent: 3905971 (1975-09-01), Miller
patent: 3912723 (1975-10-01), Miller
patent: 4782056 (1988-11-01), Rosner et al.
patent: 5141938 (1992-08-01), Lindner et al.
patent: 5188832 (1993-02-01), Mehlhorn et al.
patent: 5256631 (1993-10-01), Lindner et al.
Carroll, R "Anticoccidial Derivatives of 6-Azauracil. 5. Potentiation by Benzophenone Side Chains" J. Med. Chem. 1983, 26, 96-100.
Miki et al, Chemical Abstracts, vol. 127 (Jul. 21, 1997).
Mylari et al., "Anticoccidial Derivatives of 6-Azauracil. 1. Enhancement of Activity by Benzylation of Nitrogen-1. Observation on the Design of Nucelotide Analogues in Chemotherapy" J. Med. Chem. 20:475-483 (1979).
Miller et al., "Anticoccidial Derivatives of 6-Azauracil. 2. High Potency and Long Plasma Life of N1-Phenyl Structures.sup.1a " J. Med. Chem. 22:1483-1487 (1979).
Miller et al., "Anticoccidial Derivatives of 6-Azauracil. 3. Synthesis, High Activity, and Short Plasma Half-life of 1-Phenyl-6-azauracils Containing Sulfonamide Substituents" J. Med. Chem. 23:1083-1087 (1980).
Miller et al., "Anticoccidial Derivatives of 6-Azauracil. 4. A 1000-fold Enhancement of Potency by Phenyl Sulfide and Phenyl Sulfone Side Chains.sup.1 " J. Med. Chem. 24:1337-1342 (1981).
Shin Jikken Kagaku Koza, vol. 15(II), 88-93, 206-207, 323-325 and 444-447, 1977.
J.W. McFarland, et al., J. Med., Chem., 34, 1908-1911, 1991.
Monatshefte fur Chemie, 94, 258-262, 1963.
Aoki Isao
Hayashi Toshikatsu
Iwanaga Koichi
Miki Hideki
Raymond Richard L.
Takeda Chemical Industries Ltd.
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