1,2,4-Triaminobenzene derivatives useful for treating...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C549S074000, C549S075000

Reexamination Certificate

active

07368472

ABSTRACT:
The present invention concerns 1,2,4-triaminobenzene derivatives of the general formula I or pharmaceutically acceptable salts thereof and the use thereof.

REFERENCES:
patent: WO 97/15300 (1997-05-01), None
patent: WO 01/01970 (2001-01-01), None
patent: WO 01/22953 (2001-04-01), None
patent: WO 02/49628 (2002-06-01), None
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Wickenden, et al. “Retigabine, A Novel Anti-Convulsant, Enhances Activation of KCNQ2/Q3 Potassium Channels” Molecular Pharmacology, 2000, 58, 591-600.
Tober, et al. “D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures” European Journal of Pharmacology, 1996, 303, 163-169.
Wickenden, et al. “KCNQ Channel Expression in Rat DRG Following Nerve Ligation” Society for Neuroscience Abstracts, 2002, No. 454.7.
Goldstein, et al. “Localization of KCNQ and KCNE Channel Subunits in the Central and Peripheral Nervous System of the Rat” Society for Neuroscience Abstracts, 2003, No. 53.8.
Saganich, et al. “Differential Expression of Genes Encoding Subthreshold-Operaling Voltage-Gated K+ Channels in Brain” The Journal of Neuroscience, 2001, 21, 4609-4624.
Noda, et al. “KCN Channels in Glial Cells” Society for Neuroscience Abstracts, 2003, No. 53.9.

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