Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-07-07
1981-04-14
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
542425, 544367, 548133, 424272, A61K 3142, A61K 31495, C07D27106, C07D24102
Patent
active
042619947
ABSTRACT:
1,2,4-Oxadiazole derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 =H, halogen or alkyl, or two of them represent the --CH.dbd.CH--CH.dbd.CH-- group required to form a fused benzene ring and R=an amino radical NR'R" or --N.dbd.CR'.sub.3 --NR'.sub.1 R'.sub.2, in which R', R", R'.sub.1 and R'.sub.2 =alkyl, hydroxyalkyl or N,N-dialkylaminoalkyl or NRR' or NR'.sub.1 R'.sub.2 =heterocyclic ring, and R' and R" can also be H, dialkylaminoalkylcarbonyl and pyridinoalkyl, (at least two of R.sub.1 to R.sub.5 being other than H when R' and R"=H), are pharmaceutically useful as anti-hypertensive agents.
REFERENCES:
patent: 3452035 (1969-06-01), Berkelhammer et al.
patent: 3538087 (1970-11-01), Troxler et al.
patent: 3557099 (1971-01-01), Breuer
patent: 3564606 (1971-02-01), Breuer
patent: 3720685 (1973-03-01), Breuer et al.
patent: 3862168 (1975-01-01), Findeisen et al.
patent: 3879407 (1975-04-01), Hagarty
Daus Donald G.
Springer D. B.
Synthelabo
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