1,2,4-oxadiazole derivatives having monoamine oxidase B enzyme-i

Details 1,2,4-oxadiazole derivatives having monoamine oxidase B enzyme-i 1,2,4-oxadiazole derivatives having monoamine oxidase B enzyme-i

1992-01-31

1994-10-18

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514340, 544138, 544367, 546209, 546277, 548131, C07D27106, A61K 3141

Patent

active

053569164

ABSTRACT:
A 1,2,4-oxadiazole derivative is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a lower alkyl or cycloalkyl group, a lower alkyl group substituted with a halogen atom, a lower alkylamino group or a phenyl group; R.sup.2 represents a hydrogen atom, a lower dialkylamino group, a cyclic alkylamino group, a cyclic amino group having an oxygen or nitrogen atom in the ring, a phenyl group which may be substituted with a halogen atom, a pyridyl group, an imidazolyl group, an alkylimidazolyl group, a benzimidazolyl group or a 2-oxopyrrolidinyl group; and n is 1, 2 or 3. The derivative has excellent monoamine oxidase-inhibitory activity and is effective as a medicine for treating Parkinson's disease.

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