1,2,4-oxadiazole and 1,2,4-thiadiazole derivatives of fenamates

Details 1,2,4-oxadiazole and 1,2,4-thiadiazole derivatives of fenamates 1,2,4-oxadiazole and 1,2,4-thiadiazole derivatives of fenamates

1991-05-09

1992-05-19

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548132, 548133, 548128, 548129, 514364, A61K 3141, C07D27106, C07D28508, C07D28514

Patent

active

051149583

ABSTRACT:
1,2,4-Oxadiazole and 1,2,4-thiadiazole derivatives of the fenamic acids, in which the fenamate residue is present at the 3-position of the 1,2,4-oxadiazole or 1,2,4-thiadiazole, pharmaceutically acceptable acid addition or base salts and methods of preparation for such compounds as well as pharmaceutical compositions alone or in combination with a second active ingredient are described. The compounds are active as inhibitors of cyclooxygenase and/or 5-lipoxygenase thereby providing methods of treatment for antiinflammatory diseases.

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