1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548131, 548132, 548133, 548129, 548122, 5483171, 5483201, 544 68, 5142292, 514360, 514361, 514363, 514396, 514397, 514398, 514399, 514400, A61K 3141, C07D271113, C07D27106

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active

059589582

ABSTRACT:
1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.

REFERENCES:
patent: 2049582 (1936-08-01), Ziegler
patent: 3109848 (1963-11-01), Bortnick et al.
patent: 3121093 (1964-02-01), Bortnick et al.
patent: 3132151 (1964-05-01), Bortnick et al.
patent: 3501487 (1970-03-01), Poos
patent: 3563994 (1971-02-01), Wollweber et al.
patent: 3694432 (1972-09-01), Hershenson
patent: 3725435 (1973-04-01), Poos
patent: 3816457 (1974-06-01), Grisar et al.
patent: 4046909 (1977-09-01), Rasmussen et al.
patent: 4061746 (1977-12-01), Blohm et al.
patent: 4126613 (1978-11-01), Grisar et al.
patent: 4126621 (1978-11-01), Grisar et al.
patent: 4153235 (1979-05-01), Grisar et al.
patent: 4443468 (1984-04-01), Maillard et al.
patent: 4523020 (1985-06-01), Moormann et al.
patent: 4525476 (1985-06-01), Butler et al.
patent: 4533739 (1985-08-01), Pitzele et al.
patent: 4556674 (1985-12-01), Maillard et al.
patent: 4579951 (1986-04-01), Pitzele et al.
patent: 4699918 (1987-10-01), Maillard et al.
patent: 4855444 (1989-08-01), Wambach
patent: 4962204 (1990-10-01), Wambach
patent: 5015633 (1991-05-01), Sudilovsky
patent: 5028627 (1991-07-01), Kilbourn et al.
patent: 5051444 (1991-09-01), Tamoto et al.
patent: 5059712 (1991-10-01), Griffith
patent: 5081148 (1992-01-01), Braquet et al.
patent: 5132453 (1992-07-01), Griffith
patent: 5196439 (1993-03-01), Sugimoto et al.
patent: 5216025 (1993-06-01), Gross et al.
patent: 5246971 (1993-09-01), Williamson et al.
patent: 5266594 (1993-11-01), Dawson et al.
patent: 5273875 (1993-12-01), Griffith
patent: 5621004 (1997-04-01), Dunn et al.
patent: 5629322 (1997-05-01), Guthikonda et al.
Ulhaq S et al., "S-2-Amino-5-(2-nitroimidazol-1-yl)pentanoic acid: a potential biorductively-activated inhibitor of nitric oxide synthase activity for use in cancer therapy", Chemical Abstracts, vol. 125, No. 3, 1996, p. 43.
Shvachkin Y P et al., "Potential antimetobolites, XVIII. Possibility of condensing arginine with malonic ester", Chemical Abstracts, vol. 64, No. 7, 1966, Abstract No. 9720e.
Rehse K et al., "3-Amino-1,2,4-oxadiazol-5-ones as prodrugs for hydroxyguanidines", Archiv Der Pharmazie-Pharmaceutical and Medicinal Chemistry, vol. 329, No. 12, 1996, pp. 535-540.
Perrin et al., "Absence of Stereoelectronic Control in Hydrolysis of Cyclic Amidines", J. Am. Chem. Soc., vol. 108, No. 19, pp. 5997-6003, 1986.
Huber et al., "Saturated Heterocycles, Part 88. Synthesis of a New Ring Perkin Trans. 1 , pp. 909-912, 1987.
Kokosi et al., "Nitrogen Bridgehead Compounds. Part 19(1). Synthesis of Polymethylenepyrimidin-4-ones", J. Heterocyclic Chem., vol. 19, pp. 909-912, 1982.
Brown et al., Hydropyrimidines, Part II, pp. 4041-4045, 1962.
Adcock et al., 2-Amino-2-imidazolines 2-Amino-2-oxazolines, Part II, pp. 474-479, 1965.
Stefanye et al., "Cyclic Guanidines from Nitrimino Compounds", J. Am. Chem. Soc., vol. 77, No. 3, pp. 761-762, 1955.
Klayman et al., "2-Amino-2-thiazoline. VII Unequivocal Structure Assignment of the Products of the Reaction of 2-Amino-2-thiazoline and Its Analogs with Carbethoxy Isothiocyanate", J. Org. Chem., vol. 39, No. 13, pp. 1819-1823, 1974.
Moriconi et al., "Synthesis and Reactions of Cyclic Amidines", J. Org. Chem., vol. 33, No. 5, pp. 2109-2111, 1968.
Wagenaar et al., "Methodology for the Preparation of N-Guanidino-Modified Arginines and Related Derivatives", J. Org. Chem., vol. 58, No.1, pp. 4331-4338, 1993.
Gutteridge, "Acylation of 2-Amino-5,5-dimethyl-.DELTA.-pyrroline 1-Oxide", J. Chem. Soc., (C), pp. 3121-3125, 1971.
Langlois et al., "Derivatives of Imidazole, 1,3,4-triazole and tetrazole", J. Heterocycl. Chem., vol. 19, No. 1, pp. 193-200, 1982 (English Summary, p. 200).
Langlois et al., "Synthesis and Antidepressant Properties of 2-Amino-4-phenyl-1-pyrroline Derivatives", Eur. J. Med. Chem., vol. 13, No. 2, pp. 161-169, 1978 (English Summary, p. 169).
Klotzer et al. "Acylderivatives of 2-Amino-1-pyrrolines", Monatshefte fur Chemie, vol. 102, No. 2, pp. 627-634, 1971 (English Summary, p. 627).
Klotzer et al. "Synthesis of Substituted 2-Amino-1-pyrrolines, I." Monatshefte fur Chemie, vol. 101, No. 5, pp. 1263-1270, 1970 (English Summary, p. 1263).
Nakane et al., "Novel Potent and Selective Inhibitors of Inducible Nitric Oxide Synthase", Molecular Pharmacology, vol. 47, pp. 831-834, 1995.
Dunbar et al., "Design, Synthesis, and Neurochemical Evaluation of 2-Amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydopyridines and 2-Amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M.sub.1 Muscarinic Receptor Agonists", J. Med. Chem., vol. 37, No. 17, pp. 2774-2782, 1994.
Klotzer et al. "Synthesis of Substituted 2-Aminopyrrolines, II." Monatshefte fur Chemie, vol. 101, No. 6, pp. 1841-1850, 1970 (English Summary, p. 1841).
Berge et al., "Pharmaceutical Salts", J. Pharm. Sci., vol. 66, No. 1, pp. 1-19, 1977.
Moncada et al., "Nitric Oxide: Physiology, Pathophysiology, and Pharmacology", Pharmacological Reviews, vo. 43, No. 2, pp. 109-142, 1991.
Moncada et al, "Biosynthesis of Nitric Oxide from L-Arginine", Biochemical Pharm., vol. 38, No. 11, pp. 1709-1715, 1989.
Mazurek et al., "Theoretical Studies of Tautomerism of Clonidine Vacuum and in Water Medium", Theochem, 82(1-2), 23-8, 1991 (Abstract only).
Bertolini et al., "Nitric Oxide Synthase Inhibitors: Recent Advances", Cardiovascular & Renal Patent Update, Ashley Publications Ltd., pp. 1339-1345, 1994.
Culvenor, C.C.J. et al, Aust. J. Chem., 24 (1971) 371-375.
Caujolle, R. et al, Eur. J. Med. Chem. Chim. Ther., 28(1) (1993) 29-35.
Kato et al, Chem. Pharm. Bull., 20 (1972) 901.
Anderson, Wayne K. et al, Synth. Commun., 19(13-14) (1989) 2237-2242.
Olomucki et al, Biochim. Biophys. Acta, 263 (1972) 213-216.
Otake, N. et al, Tetrahedron Lett., 19 (1965) 1411-1419.
Patent: Kerin Seiyaku Kabushiki Kaisya, JP, A, 17189, 1968: Referati vnyi Zhurnal. Khimiya., 1 (1970) N469P.
Umezawa et al, J. Antibiot., 26 (1973) 625, 637.
Bycroft et al., J. Antibiot., 22 (1969) 133-134.
Bycroft et al., J. Chem. Soc.(C), (1971) 3040-3046.
Marconi et al, J. Antibiot., 23 (1970) 120-124.
Kretow et al, J. Gen. Chem. USSR, 32 (1962) 464.
Dorn et al, Chem, Ber., 103 (1970) 2505-2511.
Andrewes et al, Proc. R. Soc. London B, 133 (1946) 20, 53 (Beilstein Registry ID Only).
Schubert, H. W. et al, Arch. Pharm. Ber. Dtsch. Pharm. Ges., 301(10) (1968) 750-762.
Rodricks et al, J. Org. Chem., 36 (1971) 46-48.
Stefanye et al, J. Amer. Chem. Soc., 77 (1955) 761-762.
Goodman et al, J. Org. Chem., 23 (1958) 1954-1956.
Goodman et al, J. Org. Chem., 23 (1958) 1251-1255.
Moro et al., "cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase," Proc. Natl. Acad. Sci., vol. 93, No. 4, pp. 1480-1485, Feb. 20 1996. (supplied in parent application).

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