1,2,4,5-tetra substituted imidazoles as modulators of multi-drug

Details 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug

1995-06-07

1997-12-23

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514398, 514399, 546 94, 5483154, 5483381, 5483355, 5483435, A01K 31415, C07D23304, C07D23361, C07D23356

Patent

active

057008264

ABSTRACT:
This invention relates to compounds of Formula 1 which are pharmacologically useful for the treatment of cancer through sensitization of multi-drug resistant cancer cells to chemotherapeutic agents. ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are, respectively hydrogen, alkyl, alkenyl, substituted alkyl, substituted alkenyl, aryl, substituted aryl.

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