1,2,3-trisubstituted indoles for treatment of inflammation

Details 1,2,3-trisubstituted indoles for treatment of inflammation 1,2,3-trisubstituted indoles for treatment of inflammation

1984-06-01

1987-03-31

Hendricks, Glenna M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548483, 548484, 548485, 548486, C07D20930, C07D20940, A61K 3140

Patent

active

046543600

ABSTRACT:
Disclosed are compounds of the formula ##STR1## wherein the several groups are defined herein. These compounds are useful for treating inflammation.

REFERENCES:
patent: 3441570 (1969-04-01), Meyer
patent: 3489770 (1970-01-01), Herbst
patent: 3665016 (1972-05-01), Bourdais
patent: 3860609 (1975-01-01), Lundt
patent: 4428962 (1984-01-01), Bristol et al.
Tomita et al., "The Reaction of Indoles with Succinimido-Sulfonium Salts . . . ", Chem. Abst. 85:46294(1976).
Nagarathnam et al., "1 Benzenesulfonyl-2-Bromomethyl-3-phenylthio Indole . . . ", Chem. Abst. 101:54848e (1984).
Nagarathnam et al., "1 Benzenesulfonyl-2-Bromomethyl-3-Phenylthio Indole," Chem. Abst. 98:197932, (1983).
Noller, Carl, Textbook of Organic Chemistry, W. B. Saunders, Philadelphia (1966), p. 258.

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