1,2,3-Triazole nucleosides

Details 1,2,3-Triazole nucleosides 1,2,3-Triazole nucleosides

1972-09-28

1976-07-06

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424180, C07H 1904

Patent

active

039681033

ABSTRACT:
Novel substituted 1,2,3-triazole nucleosides such as 4-R'-2-.beta.-D-ribofuranosyl-1,2,3-triazole wherein R' is a nitro, carboxylic acid ester, cyano, carboxamide or thiocarboxamide group are prepared by a procedure entailing fusion of an appropriately substituted 1,2,3-triazole with a tetra-0-acyl blocked ribofuranose. The resulting compounds exhibit significant antimicrobial activity in in vitro testing or are useful in preparing compounds which exhibit such activity.

REFERENCES:
tipson, Advances In Carbohydrate Chemistry and Biochemistry vol. 25, Academic Press, New York, N.Y., 1970 pp. 387 & 388.
Alonso et al., "Jour. Hetero. Chem." vol. 7, 1970, pp. 1269-1272.

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