1,2,3-triazole derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548255, A61K 3141, C07D24904

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active

055233104

ABSTRACT:
The invention relates to a compound of the formula ##STR1## wherein the substituents are as defined herein; its tautomer wherein the hydrogen of the triazole ring occupies position 1 of the triazole ring, and a pharmaceutically acceptable salt of the compound of formula I wherein R.sup.3 is --OH or its tautomer wherein the hydrogen of the triazole ring occupies position 1 of the triazole ring. The compounds of formula I and their salts possess inflammation inhibiting properties and are therefore useful in the treatment of inflammations such as inflammatory joint disease, for example, arthritis. In another aspect, the invention relates to pharmaceutical compositions and methods of use comprising the compounds of formula I.

REFERENCES:
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patent: 5189048 (1993-02-01), Carini et al.
Chem. Ber. vol. 106, pp. 2758-2766 (1973), Beck, G.
Int. J. Immunopharma, 12: pp. 703-712 (1990), Hanglow, A. C.
Amer. J. Clin. Path. 35: pp. 223-232 (1961) Goodwin, J. F.
Anal. Biochem. 86: pp. 248-254 (1976) Bradford, M. M.

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