Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-12-05
1996-06-04
Haley, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548255, A61K 3141, C07D24904
Patent
active
055233104
ABSTRACT:
The invention relates to a compound of the formula ##STR1## wherein the substituents are as defined herein; its tautomer wherein the hydrogen of the triazole ring occupies position 1 of the triazole ring, and a pharmaceutically acceptable salt of the compound of formula I wherein R.sup.3 is --OH or its tautomer wherein the hydrogen of the triazole ring occupies position 1 of the triazole ring. The compounds of formula I and their salts possess inflammation inhibiting properties and are therefore useful in the treatment of inflammations such as inflammatory joint disease, for example, arthritis. In another aspect, the invention relates to pharmaceutical compositions and methods of use comprising the compounds of formula I.
REFERENCES:
patent: 4908363 (1990-03-01), Klotzer et al.
patent: 5189048 (1993-02-01), Carini et al.
Chem. Ber. vol. 106, pp. 2758-2766 (1973), Beck, G.
Int. J. Immunopharma, 12: pp. 703-712 (1990), Hanglow, A. C.
Amer. J. Clin. Path. 35: pp. 223-232 (1961) Goodwin, J. F.
Anal. Biochem. 86: pp. 248-254 (1976) Bradford, M. M.
Gould George M.
Haley Jacqueline
Hoffmann-La Roche Inc.
Johnston George W.
Silverman Robert A.
LandOfFree
1,2,3-triazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,2,3-triazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,2,3-triazole derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-383571