1,2,3-Thiadiazole process

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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544284, 544293, A61K 31505

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active

041713630

ABSTRACT:
A series of novel 4-amino-2-(thiadiazole-carbonyl piperazinyl)-6,7-dimethoxyquinazolines is disclosed having antihypertensive properties. The thiadiazole substituent may be optionally substituted with alkyl or lower alkoxy carbonylamino groups. A representative embodiment of the invention is 4-amino-6,7-dimethoxy-2-[4-(5-ethoxy-carbonylamino-1,2,3-thiadiazole-4-car bonyl)-piperazin-1-yl]-quinazoline.

REFERENCES:
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patent: 3517005 (1970-06-01), Cronin et al.
patent: 3594480 (1971-07-01), Cronin et al.
patent: 3635979 (1972-01-01), Hess et al.
patent: 3663706 (1972-05-01), Hess
patent: 3669968 (1972-06-01), Hess
patent: 3769286 (1973-10-01), Hess
patent: 3780040 (1973-12-01), Schnettler et al.
patent: 3812127 (1974-05-01), Cronin et al.
patent: 3920636 (1975-11-01), Takahashi et al.
patent: 4001237 (1977-01-01), Partyka
patent: 4001238 (1977-01-01), Partyka et al.
Chem. Abs., vol. 78, 1973, p. 480, Ab. No. 72180s.

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