1,2,3-Thiadiazole amides

Details 1,2,3-Thiadiazole amides 1,2,3-Thiadiazole amides

1977-02-22

1978-07-18

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424251, 544293, 544291, 544285, C07D23984

Patent

active

041015487

ABSTRACT:
A series of novel 4-amino-2-(thiadiazole-carbonyl piperazinyl)-6,7-dimethoxyquinazolines is disclosed having antihypertensive properties. The thiadiazole substituent may be optionally substituted with alkyl or lower alkoxy carbonylamino groups. A representative embodiment of the invention is 4-amino-6,7-dimethoxy-2-[4-(5-ethoxy-carbonylamino-1,2,3-thiadiazole-4-car bonyl)-piperazin-1-yl]-quinazoline.

REFERENCES:
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patent: 3920636 (1975-11-01), Takahashi et al.
patent: 4001237 (1977-01-01), Partyka et al.
patent: 4001238 (1977-01-01), Partyka et al.
Chemical Abstracts, vol. 78, 1973, 72180s, p. 480.

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