1,2,3,5-Tetrahydroimidazothienopyrimidin-2-ones

Details 1,2,3,5-Tetrahydroimidazothienopyrimidin-2-ones 1,2,3,5-Tetrahydroimidazothienopyrimidin-2-ones

1979-08-13

1981-08-18

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544250, 424251, C07D49514, A61K 31505

Patent

active

042847737

ABSTRACT:
A 1,2,3,5-tetrahydroimidazothienopyrimidin-2-one represented by the formula: ##STR1## wherein one of Z.sub.1, Z.sub.2 and Z.sub.3 is a sulfur atom and the remaining two of Z.sub.1, Z.sub.2 and Z.sub.3 represent CH, R.sub.1 and R.sub.2 each represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group, a chlorine atom or, when taken together R.sub.1 and R.sub.2 represent an alkylene chain of 3 to 5 carbon atoms, and R.sub.3 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and a pharmaceutically acceptable acid addition salt thereof, which exhibit an excellent blood platelet anti-aggregatory activity and are useful as anti-thrombotic agents.

REFERENCES:
patent: 3890321 (1975-06-01), DeAngelis et al.
Sauter et al., Monatsh. Chem. (1978), 109(1), 53-61.

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