1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines

Details 1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines 1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines

1978-11-03

1980-02-12

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544349, A61K 31495, C07D48704

Patent

active

041883896

ABSTRACT:
1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine derivatives characterized by having a lower alkyl, cyclo(lower)alkyl, phenyl or substituted phenyl at position 1 of the nucleus and optionally further substituted at position 2 of the nucleus with a lower alkyl, cyclo(lower)alkyl, phenyl(lower)alkylene or 2-(indole-3-yl)ethyl are disclosed. The derivatives are useful antidepressant agents. Methods for their preparation also are disclosed.

REFERENCES:
patent: 2655512 (1953-10-01), Dunlop et al.
patent: 2673850 (1954-03-01), Stoll et al.
patent: 3164598 (1965-01-01), Freed
patent: 4093616 (1978-06-01), Kuhla
patent: 4097598 (1978-06-01), Kuhla
Herz et al., "J. Amer. Chem. Soc.", vol. 77 (1955), pp. 6355-6357.
Dunlop et al., "Chem. Abstracts," vol. 48 (1954), Col. 11495f.
Flament et al., "Helvetica Chimica Acta", vol. 60 (1977), pp. 1872-1883.
Morimoto et al., "Chemical Abstracts", vol. 82 (1975), Col. 140180b.
Morimoto et al., "Chemical Abstracts", vol. 82 (1975), Col. 156398q.
Morimoto et al., "Chemical Abstracts", vol. 82 (1975), Col. 125416q.

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