1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives

Details 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives

1993-06-11

1995-01-03

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544116, C07D48704, A61K 31495

Patent

active

053788460

ABSTRACT:
1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives having the formula (Formula I) ##STR1## and therapeutically acceptable acid addition salts thereof (Formula I.HX), wherein: R.sup.1 =hydrogen or acyl groups; and R.sup.2 =hydrogen or substituted aminomethyl groups. Said compounds and their acid addition salts have psychotropic activity, particularly anxiolytic activity.

REFERENCES:
patent: 4188389 (1980-02-01), Jirkovsky
patent: 4216321 (1980-08-01), Skoldinov et al.
patent: 4230856 (1980-10-01), Skoldinov et al.
M. Abou-Gharbia, "Synthesis and Structure-Activity Relationship of Substituted Tetrahydro- and Hexahydro-1,2-benzisothiazol-3-one 1,1-Dioxides and Thiadiazinones: Potential Anxiolytic Agents", J. Med. Chem., 32 1024-1033 (1989).
V. Persesada et al., "Azacycloalkanes. XXX. Pyrrolo [1,2-a] Pyrazines with Variable Degrees of Pyrazine Ring Saturation and Their Hypotensive Activity", Pharmaceutical Chemistry Journal, 21(9) 619-624 (1988). This is an English translation of the Russian-language article appearing in Chem.-Pharmac. J., 21(9), 1054-1059 (1987).
V. Peresada et al., "Azacycloalkanes. XXXI: Arylalkylpyrolo(1,2-a)pyrazines and their effects on ischemized myocardium", Pharmaceutical Chemistry Journal, 22(10) 755-759 (1988). This is an English translation of the Russian-language article appearing in Chem.-Pharmac. J., 22(10), 1193-1197 (1988).

Affiliated with

Also associated with

Rating

1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2212605