Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1978-07-26
1980-10-28
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
424250, A61K 31495, C07D48704
Patent
active
042308569
ABSTRACT:
1,2,3,4-Tetrahydropyrrolo-[1,2-a]-pyrazine of the formula: ##STR1## is disclosed together with a method for preparing the same which comprises reducing 3,4-dihydropyrrolo-[1,2-a]-pyrazine, in a medium of an organic solvent, by way of hydrogenation with hydrogen or complex hydrides of metals. When using hydrogen said hydrogenation is effected in the presence of a catalyst of the group of platinum. The desired product is then isolated from the reaction mixture. The resulting 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine may be used as the starting product for the synthesis of physiologically active compounds such as octahydropyrrolo-[1,2-a]-pyrazine which serves as the basis for the preparation of coronary-dilating and neuroleptic compounds. The method for preparing 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine is technologically simple and may be readily implemented on a commercial scale.
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Likhosherstov Arkady M.
Peresada Vitaly P.
Skoldinov Alexandr P.
Adams Bruce L.
Burns Robert E.
Daus Donald G.
Lobato Emmanuel J.
Turnipseed James H.
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