1,2,3,4-Tetrahydronaphthalene derivatives

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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564222, 564428, 424330, A61K 31165, C07C103365

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active

044421265

ABSTRACT:
New compounds of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or an alkanoyl group containing from 1 to 4 carbon atoms, R.sub.2 and R.sub.3 each represent a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, and R.sub.4 represents a hydroxy or methoxy group in the 6-position or 7-position, have been found to be useful in therapy, and more particularly in the treatment of cardiovascular diseases and Parkinson's disease.

REFERENCES:
patent: 3991207 (1976-11-01), Sarges et al.
patent: 4320148 (1982-03-01), De Marinis
Chemical Abstracts, vol. 54, Abstract No. 7659d, 1955, Ward, E. R. et al., "Isomer Ratios in the Nitration of 6-Acylamino-1,2,3,4-tetrahydronaphthalene".
Chemical Abstracts, vol. 65, Abstract No. 663c, 1966, Hecker et al., "Radical Hydroxylation of 6-Tetralol with Fenton's Reagent".

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