1,2,3,4-Tetrahydroisoquinolines 6.10,7,8 dihydroxy substitute-1-

Details 1,2,3,4-Tetrahydroisoquinolines 6.10,7,8 dihydroxy substitute-1- 1,2,3,4-Tetrahydroisoquinolines 6.10,7,8 dihydroxy substitute-1-

1980-01-04

1984-05-08

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546146, 546150, A61K 3147, C07D21704

Patent

active

044474369

ABSTRACT:
1,2,3,4-Tetrahydroisoquinolines having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkenyl, acyl, aryl or ar(lower)alkyl, in which aryl and the aryl moiety of the ar(lower)alkyl may contain at least one substituent selected from the group consisting of halogen, lower alkoxy, amino, nitro, hydroxy, acyloxy, ar(lower)alkoxy, lower alkylenedioxy, halo(lower)alkyl, acylamino, ar(lower)alkylamino and aryl, and pharmaceutically acceptable salts thereof, having a relaxant activity on smooth muscles.

REFERENCES:
patent: 3378561 (1968-04-01), Montzka
patent: 3389140 (1968-06-01), Montzka
patent: 3846432 (1974-11-01), Tanaka et al.
patent: 4220647 (1980-09-01), Kishimoto et al.

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