1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation t

Details 1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation t 1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation t

1980-10-29

1983-01-25

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424250, 424251, 544238, 544316, 544363, 546148, 546 90, 546140, 546147, 260155, A61K 3147, C07D40912

Patent

active

043703321

ABSTRACT:
A 1,2,3,4-tetrahydroisoquinoline having smooth muscle relaxant activity of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or lower alkyl, R.sub.3 is phenyl having substituents selected from the group consisting of lower alkenyloxy, mercapto, lower alkylthio, sulfamoyl and mono or disubstituted sulfamoyl, or a heterocyclic group, R.sub.4 and R.sub.5 are each hydroxy or protected hydroxy and X is --O-- or--S--.

REFERENCES:
patent: 3378561 (1968-04-01), Montzka
patent: 3389140 (1968-06-01), Montzka
patent: 3389141 (1968-06-01), Montzka
patent: 3437662 (1969-04-01), Geldersteve et al.
patent: 3452086 (1969-06-01), Montzka
patent: 3846432 (1974-11-01), Tanaka et al.
patent: 3963725 (1976-06-01), Kishimoto et al.
patent: 4096263 (1978-06-01), Kishimoto et al.

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