1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans useful as ana

Details 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans useful as ana 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans useful as ana

1985-12-30

1987-05-26

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514222, 514227, 514253, 514378, 514256, 514337, 514381, 514365, 514372, 514383, 514374, 514397, 514406, 514422, 514444, 514468, 544 60, 544 63, 544 96, 544153, 544238, 544333, 544375, 544405, 546196, 546269, 548203, 548214, 548235, 548247, 548255, 548262, 548336, 548374, 548525, 549 60, 549460, 564442, A61K 3134, C07D30791

Patent

active

046686908

ABSTRACT:
This invention relates to 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans of the formula ##STR1## where X is hydrogen, loweralkyl, F and Cl; R.sub.1 is hydrogen, loweralkyl, arylloweralkyl, loweralkenyl, loweralkoxyloweralkyl, aryloxyloweralkyl, cycloalkylloweralkyl and heteroarylloweralkyl: R.sub.2 is hydrogen, lower alkyl or R.sub.1 and R.sub.2 taken together with the N ring atom constitute a saturated or unsaturated heterocyclic ring having 5 or 6 members; R.sub.3 is hydrogen, lower alkyl; n is an interger of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and where applicable the stereo, optical and geometrical isomers of the foregoing.

REFERENCES:
patent: 3496181 (1970-02-01), Skaletsky et al.
patent: 4409221 (1983-10-01), Lombourieu et al.
Cassis et al., J. Heterocyclic Chem., 21, p. 869, (1984).
Burke, Jr. et al., J. Org. Chem., 49, p. 2508, (1984).
Mokatoff et al., J. Org. Chem. 33(9), p. 3551, (1968).
Schultz et al., J. A. C. S. 99, p. 8065, (1977).
Martin et al., J. Org. Chem. 46, p. 3567, (1981).
Martin et al., J. Org. Chem., 47, p. 1513, (1982).

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