1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the trea

Details 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the trea 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the trea

1985-01-28

1986-11-11

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514411, C07D20956, A61K 3140

Patent

active

046224050

ABSTRACT:
Disclosed herein are 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles represented by the formula ##STR1## wherein R.sub.1 is hydrogen, loweralkyl of 1 to 5 carbon atoms, arylalkyl, loweracyl or benzoalkylenedioxy; R.sub.2 and R.sub.3 may be the same or different and are hydroxy, loweralkoxy, halo, thiomethyl, loweracyl, NR.sub.4 R.sub.5, NHSO.sub.2 R.sub.6 or arylalkoxy or R.sub.2 and R.sub.3 taken together may form a methylenedioxy or ethylenedioxy bridge; R.sub.4 and R.sub.5 may be the same or different and are hydrogen, loweralkyl of 1 to 2 carbon atoms or loweracyl; and R.sub.6 is hydrogen or loweralkyl of 1 to 2 carbon atoms.

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Horning et al, JACS, 73; 5826, 1956.
Merck Index, 9th edition, 2925, Methyldopa.
Merck Index, 9th edition, 2353, Clonidine.

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