1-[2-(2,4-dichlorophenyl)-2-(4-substituted piperazine)ethyl]-1H-

Details 1-[2-(2,4-dichlorophenyl)-2-(4-substituted piperazine)ethyl]-1H- 1-[2-(2,4-dichlorophenyl)-2-(4-substituted piperazine)ethyl]-1H-

1986-03-17

1987-11-10

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

514252, C07D40306, C07D40314, A61K 31495

Patent

active

047058552

ABSTRACT:
Compounds of formula I ##STR1## wherein R is a phenyl group; a phenyl group mono- or di-substituted by halogen atoms, methyl, methoxy, nitro, or trifluoromethyl group; or a 2-, 3- or 4-pyridyl group; and pharmaceutically acceptable acid addition salts thereof.
Compounds I are prepared by reacting N-substituted piperazines with 1-(2',4'-dichloro-benzoylmetyl)-imidazole, optionally reducing thereafter the resulting enamines.
Compounds I have antimycotic and antibacterial activities, higher than those of known comparison drugs.

REFERENCES:
The Merck Index, 9th edition, 1976, 6043.
Godefroi et al., CA 72-90466v.

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