1,1A,6,10B-Tetrahydro-1,6-methano-dibenzo[a,e]cyclopropa[c]cyclo

Details 1,1A,6,10B-Tetrahydro-1,6-methano-dibenzo[a,e]cyclopropa[c]cyclo 1,1A,6,10B-Tetrahydro-1,6-methano-dibenzo[a,e]cyclopropa[c]cyclo

1974-12-06

1976-08-10

Todd, G. Thomas

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424330, A61K 922

Patent

active

039742849

ABSTRACT:
Compounds of the class of 1,1a,6,10b-tetrahydro-1,6-methano-dibenzo[a,e]cyclopropa[c]cycloheptene derivatives and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties and are active ingredients for therapeutic compositions. In particular, these new compounds have an antidepressive and stimulating action. Specific embodiments are N-methyl-1,1a,6,10b-tetrahydro-1,6-methano-dibenzo[a,e]cyclopropa[c]cycloh eptene-11-amine-hydrochloride, N,N-dimethyl-1,1a,6,10b-tetrahydro-1,6-methano-dibenzo[a,e]cyclopropa[c]cy cloheptene-11-amine-fumarate,N-methyl-1,1a,6,10b-tetrahydro-1,6-methano-dib enzo[a,e]cyclopropa[c]cycloheptene-11-methylamine-maleate, N,N-dimethyl-1,1a,6,10b-tetrahydro-1,6-methano-dibenzo[a,e]cyclopropa[c]cy cloheptene-11-methylamine-hydrochloride,N,N-dimethyl-11-hydroxy-1,1a,6,10b- tetrahydro-1,6-methano-dibenzo[a,e]cyclopropa[c]cycloheptene-11-methylamine -fumarate and N,N-dimethyl-11-hydroxy-1,1a,6,10b-tetrahydro-1,6-methano-dibenzo[a,e]cycl opropa[c]cycloheptene-11-ethylamine-hydrochloride.

REFERENCES:
patent: 3883537 (1975-05-01), Schroter
Cioranescu et al., Rev. Roum. Chim. 14 (7), pp. 911-27 (1969).
Cristol et al., J. Am. Chem. Soc. 90 (20), pp. 5564-5571 (1968).
Ioan et al., Tetrahedron Letters 38, pp. 3383-3386 (1965).

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