1,10-phenanthroline derivatives and use in fluorescence immunoas

Details 1,10-phenanthroline derivatives and use in fluorescence immunoas 1,10-phenanthroline derivatives and use in fluorescence immunoas

1985-08-08

1988-09-20

Warden, Robert J.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436546, 436547, 436800, 436805, 544342, 546 88, G01N 3353, C07D47104

Patent

active

047725630

ABSTRACT:
1,10-phenanthroline-2,9-dicarboxylic acid and novel derivatives thereof such as 4,7-diphenyl-1,10-phenanthroline-2,9-dicarboxylic acid and 4,5,9,14-tetraaza-(1,2,3,4)-dibenzanthracene-3,5-dicarboxylic acid can be coupled to proteins through coupling groups to form conjugates which form higly fluorescent chelates in the presence of lanthanide salts. Derivatives of the above acids reactive toward proteins can be readily manufactured by relatively simple synthetic routes, and are useful in fluorescent immunoassay.

REFERENCES:
patent: 3338906 (1967-08-01), Dwyer
patent: 3389143 (1968-06-01), Halpern
patent: 3426026 (1969-02-01), Ennis
patent: 4374120 (1983-02-01), Soini et al.
patent: 4637988 (1987-01-01), Hinshaw
patent: 4699978 (1987-10-01), Barton
Leif, R. C., et al., "Development of Instrumentation and Fluorochromes for Automated Multiparameter Analysis of Cells", Clin. Chem., 23/8, 1492-1498, (1977).
Sinha, A. P. B., "Fluorescence and Laser Action in Rare Earth Chelates", Spectroscop. Inorg. Chem., 2, 255, (1971).
Bhaumik, M. L. et al., "Stroboscopic Time-Resolved Spectroscopy", Rev. Sci. Instr., 36, 37, (1965).
Bhaumik, M. L., "Mechanism and Rate of the Intramolecular Energy Transfer Process in Rare-Earth Chelates", J. Chem. Phys., 42, 747, (Jan. 1965).
Bhaumik, M. L. et al., "Fluorescence Quantum Efficiency of Rare-Earth Chelates", J. Opt. Soc. Am., 54, 1211, (Oct. 1964).
Gillard, R. D. et al., "Optically Active Co-ordination Compounds. Part XX. Reactions of 1,10-Phenanthroline Co-ordinated to Cobalt", J. Chem. Soc. (A), 1970, 1447.
Dickeson, J. E. et al., "Derivatives of 1,10-Phenanthroline-5,6-Quinone", Aust. J. Chem., 1970, 23, 1023-7.
Chandler, C. J. et al., "Synthesis of Some 2,9-Disubstituted-1,10-Phenanthrolines", J. Heterocyclic Chem., 18, 599, (1981).
Newkone, G. R. et al., ".alpha.-Methyl Functionalization of Electron-Poor Heterocycles", J. Orgn. Chem., 1983, 48, 5112-5114.
Substituted 1,10-Phenanthrolines, XII. Benzo and Pyrido Derivatives, Emil Koft & Francis H. Case, Department of Chemistry, Temple University, Journal of Organic Chemistry, pp. 865-868, vol. 27, 1962.
Substituted 1,10-Phenanthrolines, VI. Chloro Derivatives, Francis H. Case, Sigmund Catino & Frank Scholnic, Department of Chemistry, Temple University, Journal of Organic Chemistry, pp. 31-36, vol. 19, 1954.
The Synthesis of Certain 4-Mono- and 4,7-Dihydroxy-1,10-Phenanthrolines, Case, Department of Chemistry, Temple University, Journal of Heterocyclic Chemistry, vol. 7, pp. 647-649, 1970.
Substituted 1,10-Phenanthrolines. VII. Synthesis of Certain Phenanthrolines for Use in the Detection of Cu(I).sup.1, Francis Case & James Brennan, Chemistry Department, Temple University, Journal of Organic Chemistry, vol. 19, pp. 912-922, 1954.
Substituted 1,10-Phenanthrolines. IX. Cycloalkeno Derivatives, Francis Case, Chemistry Department of Temple University, Journal of Organic Chemistry, vol. 21, pp. 1069-1071, 1956.
Synthesis of Certain Polyalkyl Quinolines and 1,10-Phenanthrolines, K. C. John & Francis H. Case, Chemistry Department, Temple University, vol. 13, No. 4, Journal of Chemical and Engineering Data, Oct. 1968, pp. 568-570.
The Synthesis of Polymethylquinolines and 1,10-Phenanthrolines (1), Case & Wisneski, Department of Chemistry, Temple University, Journal of Heterocyclic Chemistry, vol. 5, pp. 789-792, 1968.
Substituted 1,10-Phenanthrolines. XIII. The Synthesis of New 4-Mono- and 4,7-Dialkyl- and -aryl-1,10-Phenanthrolines, Case & Strohm, Chemistry Department, Temple University, Journal of Organic Chemistry, vol. 27, pp. 1641-1643, 1962.
Substituted 1,10-Phenanthrolines. X. Ethyl Derivatives, Case, Jacobs, Cook & Dickstein, Department of Chemistry of Temple University, Journal of Organic Chemistry, vol. 22, pp. 390-393, 1957.
Substituted 1,10-Phenanthrolines. VIII. 2- and 2-Phenyl Derivatives, Case & Sasin, Department of Chemistry, Temple University, Journal of Organic Chemistry, vol. 20, pp. 1330-1336, 1955.
J. R. Geigy, 2,9-Dimethyl-1,10-Phenanthroline. Chemistry Abstract, vol. 48, 1953, 7644.
Monsanto Chemicals (Australia) Ltd., 1,10-Phenanthroline Derivatives, Chemical Abstract, vol. 63, 1965, 11518.
Chemical Abstracts, 63:11519d, (1965).
Chemical Abstracts, 69:10426g, (1968).
Chemical Abstracts, 78:124565t, (1973).
Chemical Abstracts, 79:105229r, (1973).
Chemical Abstracts, 79:105230j, (1973).
Chemical Abstracts, 80:95912n, (1974).
95913p, 1,10-Phenanthroline Derivatives, vol. 80, 1974, Chemical Abstracts, p. 412.
Advances in Heterocyclic Chemistry, Lindsay A. Summers, Academic Press, vol. 22, 1978, The Phenanthrolines, pp. 1-69.
Heterocyclic Compounds, Robert C. Elderfield, John Wiley & Sons, Inc., 1961, Phenanthrolines, Chapter 4, pp. 344-383.
A Review of Fluoroimmunoassay and Immunofluorometric Assay, D. S. Smith, Mohammad Hal-Hakiem and J. Landon, Ann. Clin. Biochem., 1981; 18:253-274.

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