1-[(10,11-Dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)methyl]-4-sub

Details 1-[(10,11-Dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)methyl]-4-sub 1-[(10,11-Dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)methyl]-4-sub

1978-06-16

1980-02-12

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424267, 546 19, 546188, 546196, 546203, 546216, C07D40506, C07D40906, C07D21158, C07D21148

Patent

active

041884850

ABSTRACT:
The invention encompasses 1-[10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methyl]-4-substituted piperidines and related compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable acid addition salts thereof; wherein R in each occurrence represents hydrogen, halogen, alkyl radical of 1 to 7 carbon atoms, or trifluoromethyl, alike or different; R.sup.1 is hydrogen or alkyl radical of 1 to 7 carbon atoms; Z is hydroxy or NR.sup.2 R.sup.3 group wherein R.sup.2 and R.sup.3 are each hydrogen or alkyl radical of 1 to 7 carbon atoms or R.sup.2 and R.sup.3 together with the N-atom represent an azamonocyclic ring which contains from 4 to 6 carbon atoms; X is ethylene, vinylene, oxy or thio; and m and n are each alike or different integer from 1 to 4 inclusive; and 1-(2,2-diarylethyl)-4-piperidinols of the formula ##STR2## and the non-toxic pharmaceutically acceptable acid addition salts thereof; wherein Ar is phenyl optionally substituted with one or more halogen or alkyl radical of 1 to 7 carbon atoms, alike or different; Ar.sup.1 is phenyl optionally substituted with one or more halogen or alkyl radical of 1 to 7 carbon atoms alike or different; and R.sup.4 is selected from the group consisting of hydrogen alkyl radical of 1 to 7 carbon atoms, 4-hydroxy-1-(2,2-diphenylethyl)-3-piperidinyl, and 4-oxo-1-(2,2-diphenylethyl)-3-piperidinyl. These compounds possess utility as neuroleptic agents.

REFERENCES:
patent: 2629719 (1953-02-01), Cusic
patent: 3313810 (1967-04-01), Nakanishi et al.
patent: 3567730 (1971-03-01), Fouche
patent: 3631052 (1971-12-01), Yale
patent: 3985751 (1976-10-01), Bruderlein et al.
Chemical Abstracts, 74:22718v (1971) [Nakanishi et al., Japanese Patent 70 28,992, 9/70].
Chemical Abstracts, 59:13935f (1963) [Rajsner et al., Coll. Czech. Chem. Comm., 28, 1031-1043 (1963)].

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