1,1-Disubstitutedcycloalkyl-, glycinamidyl-,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S414000, C514S422000, C514S428000, C514S616000, C544S169000, C548S467000, C548S527000, C548S568000, C549S072000, C564S157000

Reexamination Certificate

active

10858084

ABSTRACT:
The present application describes 1,1-disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof of Formula I:in-line-formulae description="In-line Formulae" end="lead"?P-M-M1Iin-line-formulae description="In-line Formulae" end="tail"?or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein M is a linear core. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

REFERENCES:
patent: 5849736 (1998-12-01), Wityak et al.
patent: 2004/0077635 (2004-04-01), Qiao et al.
patent: 63-238051 (1988-10-01), None
patent: 2002-326980 (2002-11-01), None
patent: WO 02/057236 (2002-07-01), None
patent: WO 2004/014844 (2004-02-01), None
patent: WO 2004/024679 (2004-03-01), None
Goto et al, STN International, HCAPLUS Database, Columbus, OH, Accession No. 2002:866813, Reg. No. 475277-15-7 (2007).
Elodi et al., “Optimization of Conditions for the Catalytic Effect of the Factor IXa- Factor VIII Complex: Probably role of the complex in the amplification of blood coagulation,”Thrombosis Research, vol. 15, pp. 617-629, 1979.
U.S. Appl. No. 10/801,518, filed Mar. 16, 2004, Pinto et al.
Jia et al., “Design, Synthesis and Biological Activity of Novel Non-Amidine Factor Xa Inhibitors. Part 1: P1structure-Activity Relationships of the Substituted 1-(2-Napthyl-1H-pyrazole-5-carboxylamides”, Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, pp. 1651-1655.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

1,1-Disubstitutedcycloalkyl-, glycinamidyl-,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,1-Disubstitutedcycloalkyl-, glycinamidyl-,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,1-Disubstitutedcycloalkyl-, glycinamidyl-,... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3816882

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.