1,1-dioxopenicillanoyl oxymethyl D-6-(.alpha.-(methyleneamino) p

Details 1,1-dioxopenicillanoyl oxymethyl D-6-(.alpha.-(methyleneamino) p 1,1-dioxopenicillanoyl oxymethyl D-6-(.alpha.-(methyleneamino) p

1989-07-24

1991-04-02

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540306, 540318, 540331, A61K 3143, C07D49908, C07D49932

Patent

active

050047388

ABSTRACT:
A pharmaceutical compound which comprises reacting the sodium penicillanic acid 1,1-dioxides with chloroiodomethane in the presence of a solvent to produce chloromethylpenicillanate 1,1-dioxides, reacting the chloromethylpenicillanate 1,1-dioxides with a sodium iodide to produce iodomethylpenicillanate 1,1-dioxides, and reacting the iodomethylpenicillanate 1,1-dioxide with sodium methampicillin and is effective in the treatment of bacterial infections in a mammal.

REFERENCES:
patent: 4342772 (1982-08-01), Godtfredsen et al.
patent: 4377590 (1983-03-01), Myers
patent: 4393001 (1983-07-01), Jasys
patent: 4432987 (1984-02-01), Barth et al.
patent: 4503040 (1985-03-01), Barth
Fu et al., Antimicrobial Agents and Chemotherapy, vol. 15, No. 2, 171-176 (1979).
Greenwood et al., J. Antimicrobial Chemotherapy, vol. 10, 117-123 (1982).

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